Heart of the Matter: Unraveling Cardiovascular Disease in Autoimmune Disorders
Mariana J. Kaplan, M.D.
NIH Distinguished Investigator
NIAMS, NIH
Mariana Kaplan, M.D., joined NIAMS as Chief of the Systemic Autoimmunity Branch in 2013. She is also Deputy Scientific Director at NIAMS. Before her appointment, she was a Professor of Medicine in the Division of Rheumatology at the University of Michigan. Dr. Kaplan obtained her medical degree at the National Autonomous University of Mexico and did her Internal Medicine Residency at the National Institute of Medical Sciences and Nutrition in Mexico City. Dr. Kaplan did her Rheumatology Fellowship and postdoctoral training at the University of Michigan, where she was a member of the faculty for 15 years and an active member of their Multidisciplinary Lupus Clinic.
In addition to her research activities, Dr. Kaplan is an active clinician and teacher. She sees lupus patients in the NIH Clinical Research Center and is involved in the development of various clinical trials for patients with autoimmune diseases at NIH. She has served in numerous roles at the American College of Rheumatology/Rheumatology Research Foundation, the American Association of Immunologists, and the Lupus Foundation of America. She was inducted to the American Society for Clinical Investigation and the Association of American Physicians (AAP) and received the Henry Kunkel Young Investigator Award and the Edmund L. Dubois Memorial Lectureship, both from the American College of Rheumatology. Dr. Kaplan received the 2015 Evelyn V. Hess Award from the Lupus Foundation of America in recognition of her significant contributions to lupus research, diagnosis, and treatment. In 2016, she received the Charles L. Christian Award for significant impact on the understanding of lupus. Dr. Kaplan is on the Editorial Board of the Journal of Clinical Investigation and Deputy Editor of Arthritis & Rheumatology. She is currently a council member at the AAP. In 2021, she was elected to the National Academy of Medicine for seminal contributions that have significantly advanced the understanding of the pathogenic role of the innate immune system in systemic autoimmune diseases, atherosclerosis, and immune-mediated vasculopathies.
Summary
Patients with systemic autoimmune diseases exhibit a significantly enhanced risk to develop premature heart attacks and strokes. The mechanisms implicated in this complication, as well as preventive and treatment strategies, have been incompletely characterized. This lecture will address the scope of the problem, the putative pathogenic pathways leading to premature vascular disease in autoimmunity and discuss potential therapeutic targets and diagnostic methods.
Learning Objectives:
1. To review the scope of the impact of cardiovascular damage in autoimmunity.
2. To explore the pathogenic mechanisms involved in this complication.
3. To review potential diagnostic tools and therapies to address premature cardiovascular disease in autoimmunity.
https://videocast.nih.gov/watch=55009 (external link)
This page was last updated on Thursday, August 22, 2024